Leonie Beljaars: search on Z-Library

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1

Drug targeting to the diseased liver

Klaas Poelstra, Jai Prakash, Leonie Beljaars

Journal:

Journal of Controlled Release

Year:

2012

Language:

english

File:

PDF, 403 KB

english, 2012

2

Pharmacokinetic and Biodistribution Profile of Recombinant Human Interleukin-10 Following Intravenous Administration in Rats with Extensive Liver Fibrosis

Heni Rachmawati, Leonie Beljaars, Catharina Reker-Smit, Anne-miek M. Van Loenen-Weemaes, Werner I. Hagens, Dirk K. F. Meijer, Klaas Poelstra

Journal:

Pharmaceutical Research

Year:

2004

Language:

english

File:

PDF, 296 KB

english, 2004

3

Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans

Beljaars, Leonie, Schippers, Marlies, Reker-Smit, Catharina, Martinez, Fernando O., Helming, Laura, Poelstra, Klaas, Melgert, Barbro N.

Journal:

Frontiers in Immunology

Year:

2014

Language:

english

File:

PDF, 3.94 MB

english, 2014

4

Albumin modified with mannose 6-phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells

Leonie Beljaars, Grietje Molema, Betty Weert, Harmke Bonnema, Peter Olinga, Geny M. Groothuis, Dirk K. Meijer, Klaas Poelstra

Journal:

Year:

1999

Language:

english

File:

PDF, 261 KB

english, 1999

5

PDGF-Receptor β-Targeted Adenovirus Redirects Gene Transfer from Hepatocytes to Activated Stellate Cells

Schoemaker, Marieke H., Rots, Marianne G., Beljaars, Leonie, Ypma, Arjen Y., Jansen, Peter L. M., Poelstra, Klaas, Moshage, Han, Haisma, Hidde J.

Journal:

Molecular Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 411 KB

english, 2008

6

Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats

Montserrat Moreno, Teresa Gonzalo, Robbert J. Kok, Pau Sancho-Bru, Marike van Beuge, Josine Swart, Jai Prakash, Kai Temming, Constantino Fondevila, Leonie Beljaars, Marie Lacombe, Paul van der Hoeven,

Journal:

Year:

2010

Language:

english

File:

PDF, 1.21 MB

english, 2010

7

Targeting of superoxide dismutase to the liver results in anti-inflammatory effects in rats with fibrotic livers

Pieter J Swart, Takashi Hirano, Mirjam E Kuipers, Yuko Ito, Catharina Smit, Mitsuru Hashida, Makiya Nishikawa, Leonie Beljaars, Dirk K.F Meijer, Klaas Poelstra

Journal:

Journal of Hepatology

Year:

1999

Language:

english

File:

PDF, 1.89 MB

english, 1999

8

354 Hepatic stellate cell specific delivery of mycophenolic acid as a strategy to treat liver fibrosis

Rick Greupink, Hester Bakker, Anne-Miek van Loenen-Weemaes, Catharina Reker-Smit, Dirk Meijer, Leonie Beljaars, Klaas Poelstra

Journal:

Year:

2003

Language:

english

File:

PDF, 125 KB

english, 2003

9

The Elusive Antifibrotic Macrophage

Adhyatmika, Adhyatmika, Putri, Kurnia S. S., Beljaars, Leonie, Melgert, Barbro N.

Journal:

Frontiers in Medicine

Year:

2015

Language:

english

File:

PDF, 708 KB

english, 2015

10

Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis

van Dijk, Fransien, Hazelhoff, Christa M., Post, Eduard, Prins, Gerian G. H., Rombouts, Krista, Poelstra, Klaas, Olinga, Peter, Beljaars, Leonie

Journal:

Year:

2020

File:

PDF, 2.14 MB

2020

11

Characterization of the anti-HIV effects of native lactoferrin and other milk proteins and protein-derived peptides

Ben Berkhout, Jeroen L.B. van Wamel, Leonie Beljaars, Dirk K.F. Meijer, Servaas Visser, René Floris

Journal:

Antiviral Research

Year:

2002

Language:

english

File:

PDF, 336 KB

english, 2002

12

Reprint of: Targeting fibrosis with selective drug carriers

Klaas Poelstra, Rick Greupink, Leonie Beljaars

Journal:

Arab Journal of Gastroenterology

Year:

2010

Language:

english

File:

PDF, 180 KB

english, 2010

13

Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation

Leonie Beljaars, Klaas Poelstra, Grietje Molema, Dirk K.F. Meijer

Journal:

Journal of Hepatology

Year:

1998

Language:

english

File:

PDF, 365 KB

english, 1998

14

Targeting tumor stromal cells through a PDGF-beta receptor binding carrier

Jai Prakash, Edwin de Jong, Eduard Post, Ara K. Mohammad, Leonie Beljaars, Klaas Poelstra

Journal:

Journal of Controlled Release

Year:

2010

Language:

english

File:

PDF, 104 KB

english, 2010

15

Cell-specific delivery of biologicals: problems, pitfalls and possibilities of antifibrotic compounds in the liver

Poelstra, Klaas, Beljaars, Leonie, Melgert, Barbro N.

Journal:

Drug Discovery Today

Year:

2013

Language:

english

File:

PDF, 248 KB

english, 2013

16

Peptide-Modified Albumin Carrier Explored as a Novel Strategy for a Cell-Specific Delivery of Interferon Gamma To Treat Liver Fibrosis

Bansal, Ruchi, Prakash, Jai, Ruijter, Marieke de, Beljaars, Leonie, Poelstra, Klaas

Journal:

Molecular Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 7.89 MB

english, 2011

17

Increased Liver Uptake and Reduced Hepatic Stellate Cell Activation with a Cell-Specific Conjugate of the Rho-kinase Inhibitor Y27632

Marike Marjolijn van Beuge, Jai Prakash, Marie Lacombe, Eduard Post, Catharina Reker-Smit, Leonie Beljaars, Klaas Poelstra

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 687 KB

english, 2011

18

Osteoprotegerin Is more than a Possible Serum Marker in Liver Fibrosis: A Study into Its Function in Human and Murine Liver

Adhyatmika, Adhyatmika, Beljaars, Leonie, Putri, Kurnia S. S., Habibie, Habibie, Boorsma, Carian E., Reker-Smit, Catharina, Luangmonkong, Theerut, Guney, Burak, Haak, Axel, Mangnus, Keri A., Post, Edu

Journal:

Year:

2020

File:

PDF, 3.85 MB

2020

19

Tumor-targeted intracellular delivery of anticancer drugs through the mannose-6-phosphate/insulin-like growth factor II receptor

Jai Prakash, Leonie Beljaars, Akshay K. Harapanahalli, Mieke Zeinstra-Smith, Alie de Jager-Krikken, Martin Hessing, Herman Steen, Klaas Poelstra

Journal:

International Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 1.08 MB

english, 2010

20

WNT-5A regulates TGF-β-related activities in liver fibrosis

Beljaars, Leonie, Daliri, Sara, Dijkhuizen, Christa, Poelstra, Klaas, Gosens, Reinoud

Journal:

American Journal of Physiology - Gastrointestinal and Liver Physiology

Year:

2017

Language:

english

File:

PDF, 1.79 MB

english, 2017

21

The Antiviral Protein Human Lactoferrin Is Distributed in the Body to Cytomegalovirus (CMV) Infection-Prone Cells and Tissues

Leonie Beljaars, Hester I. Bakker, Barry W. A. van der Strate, Catharina Smit, Adrian M. Duijvestijn, Dirk K. F. Meijer, Grietje Molema

Journal:

Pharmaceutical Research

Year:

2002

Language:

english

File:

PDF, 410 KB

english, 2002

22

Targeted imaging of integrins in cancer tissues using photocleavable Ru( ii ) polypyridine complexes as mass-tags

Han, Jiaying, Sun, Jing, Song, Shanshan, Beljaars, Leonie, Groothuis, Geny M. M., Permentier, Hjalmar, Bischoff, Rainer, Halmos, Gyorgy B., Verhoeven, Cornelia J., Amstalden van Hove, Erika R., Horvat

Journal:

Chemical Communications

Year:

2020

File:

PDF, 1.17 MB

2020

23

The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue

Leonie Beljaars, Betty Weert, Albert Geerts, Dirk K.F Meijer, Klaas Poelstra

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 567 KB

english, 2003

24

Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice

Ruchi Bansal, Jai Prakash, Eduard Post, Leonie Beljaars, Detlef Schuppan, Klaas Poelstra

Journal:

Year:

2011

Language:

english

File:

PDF, 7.68 MB

english, 2011

25

Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology

Teresa Gonzalo, Eduard G. Talman, Anke van de Ven, Kai Temming, Rick Greupink, Leonie Beljaars, Catharina Reker-Smit, Dirk K.F. Meijer, Grietje Molema, Klaas Poelstra, Robbert J. Kok

Journal:

Journal of Controlled Release

Year:

2006

Language:

english

File:

PDF, 365 KB

english, 2006

26

Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis

Beljaars, Leonie

Journal:

Frontiers in Bioscience

Year:

2002

Language:

english

File:

PDF, 325 KB

english, 2002

27

Targeting 15d-Prostaglandin J2to Hepatic Stellate Cells: Two Options Evaluated

Werner I. Hagens, Adriana Mattos, Rick Greupink, Alie de Jager-Krikken, Catharina Reker-Smit, AnneMiek van Loenen-Weemaes, Annette S. H. Gouw, Klaas Poelstra, Leonie Beljaars

Journal:

Pharmaceutical Research

Year:

2007

Language:

english

File:

PDF, 628 KB

english, 2007

28

The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins

Leonie Beljaars, René Floris, Ben Berkhout, Catharina Smit, Dirk K.F. Meijer, Grietje Molema

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 361 KB

english, 2002

29

Mannose-6-Phosphate/Insulin-Like Growth Factor-II Receptors may Represent a Target for the Selective Delivery of Mycophenolic Acid to Fibrogenic Cells

Rick Greupink, Hester I. Bakker, Harry van Goor, Martin H. de Borst, Leonie Beljaars, Klaas Poelstra

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 405 KB

english, 2006

30

143 Redirection of PDGF-receptor targeted adenovirus from hepatocytes to activated stellate cells

Marieke H. Schoemaker, Marianne G. Rots, Leonie Beljaars, Arjen Y. Ypma, Peter L.M. Jansen, Hidde J. Haisma, Klaas Poelstra, Han Moshage

Journal:

Year:

2003

Language:

english

File:

PDF, 125 KB

english, 2003

31

Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis

Beljaars, Leonie

Journal:

Frontiers in Bioscience

Year:

2002

File:

PDF, 325 KB

2002

32

Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis

Schippers, Marlies, Post, Eduard, Eichhorn, Ilse, Langeland, Jitske, Beljaars, Leonie, Malo, Madhu S., Hodin, Richard A., MillÃ¡n, JosÃ© Luis, Popov, Yury, Schuppan, Detlef, Poelstra, Klaas

Journal:

Year:

2020

File:

PDF, 2.99 MB

2020

33

A novel approach to deliver anticancer drugs to key cell types in tumors using a PDGF receptor-binding cyclic peptide containing carrier

Jai Prakash, Edwin de Jong, Eduard Post, Annette S.H. Gouw, Leonie Beljaars, Klaas Poelstra

Journal:

Journal of Controlled Release

Year:

2010

Language:

english

File:

PDF, 2.40 MB

english, 2010

34

Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo

Leonie Beljaars, Barry W.A. van der Strate, Hester I. Bakker, Catharina Reker-Smit, Anne-miek van Loenen-Weemaes, Frouwke C. Wiegmans, Martin C. Harmsen, Grietje Molema, Dirk K.F. Meijer

Journal:

Antiviral Research

Year:

2004

Language:

english

File:

PDF, 283 KB

english, 2004

35

Pharmacokinetics of a hepatic stellate cell-targeted doxorubicin construct in bile duct-ligated rats

Rick Greupink, Catharina Reker-Smit, Johannes H. Proost, Anne-miek van Loenen Weemaes, Marjolijn de Hooge, Klaas Poelstra, Leonie Beljaars

Journal:

Biochemical Pharmacology

Year:

2007

Language:

english

File:

PDF, 900 KB

english, 2007

36

Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations

Johannes H. Proost, Leonie Beljaars, Peter Olinga, Pieter J. Swart, Mirjam E. Kuipers, Catharina Reker-Smit, Geny M.M. Groothuis, Dirk K.F. Meijer

Journal:

European Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 329 KB

english, 2006

37

Targeted Therapies in Liver Fibrosis: Combining the Best Parts of Platelet-Derived Growth Factor BB and Interferon Gamma

van Dijk, Fransien, Olinga, Peter, Poelstra, Klaas, Beljaars, Leonie

Journal:

Frontiers in Medicine

Year:

2015

Language:

english

File:

PDF, 798 KB

english, 2015

38

Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P28-HSA)

Leonie Beljaars, Peter Olinga, Grietje Molema, Pieter De Bleser, Albert Geerts, Geny M. M. Groothuis, Dirk K. F. Meijer, Klaas Poelstra

Journal:

Liver International

Year:

2001

Language:

english

File:

PDF, 183 KB

english, 2001

39

Gliotoxin non-selectively induces apoptosis in fibrotic and normal livers

Werner I. Hagens, Peter Olinga, Dirk K. F. Meijer, Geny M. M. Groothuis, Leonie Beljaars, Klaas Poelstra

Journal:

Liver International

Year:

2006

Language:

english

File:

PDF, 763 KB

english, 2006

40

Targeting fibrosis with selective drug carriers

Klaas Poelstra, Rick Greupink, Leonie Beljaars

Journal:

Arab Journal of Gastroenterology

Year:

2010

Language:

english

File:

PDF, 189 KB

english, 2010

41

PEGylation of interleukin-10 improves the pharmacokinetic profile and enhances the antifibrotic effectivity in CCl4-induced fibrogenesis in mice

Adriana Mattos, Alie de Jager-Krikken, Marianne de Haan, Leonie Beljaars, Klaas Poelstra

Journal:

Journal of Controlled Release

Year:

2012

Language:

english

File:

PDF, 959 KB

english, 2012

42

Homing of negatively charged albumins to the lymphatic system: General implications for drug targeting to peripheral tissues and viral reservoirs

Pieter J Swart, Leonie Beljaars, Mirjam E Kuipers, Catharina Smit, Paul Nieuwenhuis, Dirk K.F Meijer

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 620 KB

english, 1999

43

Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell

Rick Greupink, Hester I. Bakker, Catharina Reker-Smit, Anne-miek van Loenen-Weemaes, Robbert-Jan Kok, Dirk K.F. Meijer, Leonie Beljaars, Klaas Poelstra

Journal:

Journal of Hepatology

Year:

2005

Language:

english

File:

PDF, 265 KB

english, 2005

44

HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects

Klein, Sabine, Van Beuge, Marike Marjolijn, Granzow, Michaela, Beljaars, Leonie, Schierwagen, Robert, Kilic, Sibel, Heidari, Iren, Huss, Sebastian, Sauerbruch, Tilman, Poelstra, Klaas, Trebicka, Jonel

Journal:

Journal of Hepatology

Year:

2012

Language:

english

File:

PDF, 1.42 MB

english, 2012

45

Current Concepts of Biliary Atresia and Matrix Metalloproteinase-7: A Review of Literature

Nomden, Mark, Beljaars, Leonie, Verkade, Henkjan J., Hulscher, Jan B. F., Olinga, Peter

Journal:

Frontiers in Medicine

Year:

2020

File:

PDF, 950 KB

2020

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